Differences between Prednisone and Prednisolone

One of the commonly used anti-inflammatory drugs is Prednisone. It belongs to the group of synthetic non-fluorinated glucocorticosteroids. It has active compounds that distinguish it from natural and natural preparations. Reactions that occur in the body under the influence of such compounds completely eliminate the occurrence of side effects.


The substances that make up the prednisone from stop-any-disease.com agent provoke the processes of lysosomal membranes, lower the level of proteolytic enzymes from the lysosome tissues. In addition, it contributes to the inhibition of the enzymes phospholipase and arachidonic acid. As a result of all these processes in the cells of the body, the synthesis of hydroxy acids, mediators and leukotrienes is inhibited.

As a result of taking Prednisone in the human body, the permeability of capillaries is significantly reduced and the phases of exudation and proliferation are inhibited.

The drug has an anti-allergic property due to the conductivity of mast cell degranulation, the synthesis of leukotrienes and antibodies is destroyed. It also has an anti-shock effect. This is due to an increased reaction to vascular components that stimulate the cardiovascular system. As a result of these processes, the balance of water and sodium is maintained in the tissues of the human body.

This medication improves the functioning of the nervous system and accelerates the process of synthetic corticosteroids, thereby removing toxins from the liver.

After oral administration, the medicine is quickly absorbed and reaches a peak concentration within 15 minutes. Its bioavailability is 90% and is excreted through the kidneys with urine.


Prednisone is available only in tablet form of 5, 10, 20 and 50 mg. It is prescribed for the following diseases:

  • Rheumatoid arthritis.
  • Ankylosing spondylitis.
  • Asthma.
  • Bronchitis.
  • Allergy.

These are the main diseases that are treated with this drug. But it is also used for various blood pathologies.


Doctors prescribe the dosage and time of admission for each patient individually. Basically, an adult is prescribed 50 mg per day. If necessary, increase the dosage by 10 mg.

For serious pathologies, 100 mg is used with an addition of 15 mg. During the treatment period, you need to monitor the blood sugar. But also to reduce the occurrence of side effects, it is necessary to take anabolic steroids at the same time.

During the treatment of tuberculosis, patients need to take the drug together with anti-TB drugs to prevent side effects.

For children, the dosage calculation is carried out depending on body weight – 2 mg per 1 kg. The daily dose is usually divided by 5 times.

The maximum dosage per day for an adult is approximately 100 mg. In case of a shock condition, it is allowed to administer the drug in high doses after a certain time. Dose reduction with prolonged treatment should be gradual.

When treating with this remedy, it is necessary to follow a special diet and saturate the body with potassium. In addition, an ophthalmologist should undergo an examination and monitor blood pressure.
Prolonged use of the drug can lead to an overdose. In this case, the following symptoms develop:

  • Neurological disorders.
  • Loss of concentration.
  • Dizziness and, in rare cases, fainting.
  • Drowsiness and malaise.

If these signs are found, seek medical attention. In addition, prolonged use of tablets can lead to depression, impaired taste buds, and loss of vision.


If for any reason the drug Prednisone is not suitable, analogues are prescribed. Synonyms are similar in composition and pharmacological properties. Such funds include:

  • Prednisone.
  • Candles Rectodelt.

These drugs are interchangeable and have the same characteristic properties. Most often, doctors prescribe Prednisone instead of prednisone.

There are differences between prednisone and prednisone. They may differ from each other in composition, cost and effect on the body. The main criterion that unites them is the prednisolone compound of the same name.

Means Prednisolone contains 5 mg of the active substance. A medicine is prescribed for:

  • endocrine disorders;
  • adrenal gland diseases;
  • allergies
  • rheumatic diseases;
  • violations of the liver.
  • endocrine disorders;
  • adrenal gland diseases;
  • allergies
  • rheumatic diseases;
  • violations of the liver.

Many people think that if the same content of active substance in medicines, then they are prescribed for identical pathologies. But it is not so. Prednisone tablets are strictly forbidden to use for viral diseases, ulcerative pathologies of the stomach and liver disorders. This is the main difference between the means.

In addition, the distinguishing feature is that the drug Prednisone is only in the form of tablets, and Prednisolone is found in the form of ointments, injections and tablets.

Prednisone tablets are a structural analogue of prednisone. The tablets of the first remedy contain the same component, but only in a different amount. In it, the content of the active substance can reach 50 mg.

These medicines differ in application. Since they have different contents of the active substance, the dosage will be different. The medicine Prednisolone contains a larger number of active components, which is why the maximum dose per day is 60 mg.

Another difference between Prednisone and Prednisolone is the price. Prednisone has a predominantly high cost, which is approximately 1,500 rubles per 100 tablets of 5 mg. The price of prednisolone is approximately 150 rubles per pack.


Pills have their own side effects that must be considered before starting treatment. They can be different, for example:

  • Taking the drug prevents the healing of wounds of various forms.
  • Significantly reduced resistance to infectious diseases.
  • Increases body weight.
  • The level of acidity in the stomach rises.

With the cessation of treatment, withdrawal syndrome may develop. During this period, problems with the adrenal glands arise. In rare cases, the disease exacerbated by the patient.

Before taking one of the analogues, it is necessary to study the instructions for use, familiarize yourself with the side effects and contraindications. Contraindications Prednisone include the following ailments:

  • liver and kidney diseases;
  • disorders in the cardiovascular system;
  • heart attack or stroke;
  • diabetes;
  • obesity;
  • pregnancy.

Pills are sometimes prescribed for pregnant women, but only under the strict supervision of a doctor and only in case of a threat to life.

Medicines Prednisone and Prednisone have anti-inflammatory, decongestant and analgesic effects on the body. In addition, they help to fight intoxication, increase the effectiveness of other medicines.


I was prescribed prednisone during an allergy period. To be honest, after I found out about side effects, I was afraid to take it. But when it got really bad, I had to. I was pleasantly surprised that one ampoule of this drug helped me. Now I often use this tool, of course, if necessary.

I spend most of my time at work and I just don’t have time to go to hospitals. When I started having an allergy, I did not go to the doctor, but I hoped that everything would go away by itself. In general, I reached a state where the whole body was terribly scratched, there were severe swelling. At first I was prescribed some injections, but they did not give an effect. After this, Prednisolone tablets were prescribed. They needed to drink 2 weeks. After a three-day intake, I felt much better.

I am prescribed by the doctor every year, as I have been tormented by allergies throughout the summer. He helps me well. I take 2 tablets 2 times a day from the doctor’s appointment. Then gradually reduce the dosage of daily intake.

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